منابع مشابه
Redox Regulation in Animals for Slowing Ageing
Utilization of oxygen in varieties of biochemical reactions especially, in mitochondrial electron transport chain (ETC) to reduce O2 to H2O in aerobic organisms, lead to produce several active oxygen molecules. So, mainly ETC acts as the main hub in producing partially reduced O2, as several active oxygen species. These intermediate molecules are commonly known as reactive oxygen species (ROS; ...
متن کاملRedox Status and Proteostasis in Ageing and Disease
1Department of Biomedical, Biotechnological and Translational Sciences, University of Parma, 43125 Parma, Italy 2Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, 15784 Athens, Greece 3Laboratory of Cell Signaling and Redox Biology, Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy 4Service of Endocrinolog...
متن کاملRedox regulation in cancer
Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the production of reactive oxygen species (ROS) and cell's own antioxidant defenses. ROS deregulate the redox homeostasis and promote tumor formation by initiating an aberrant induction of signaling networks that cause tumorigenesis. Ultraviolet (UV) exposures, gamma-radiation and other environmental carcinogen...
متن کاملRedox regulation
he protein that does everything, 14–3-3, has now been shown to direct traffic. Ita O'Kelly, Steve Goldstein, and colleagues (Yale University, New Haven, CT) find that 14–3-3 can displace -COP from various proteins, thus freeing them from retention in the ER and leading to surface expression. Goldstein set out to find proteins interacting with the COOH terminus of a K ϩ leak channel, KCNK3, and...
متن کاملRedox regulation in metabolic programming and inflammation
Energy metabolism and redox state are intrinsically linked. In order to mount an adequate immune response, cells must have an adequate and rapidly available energy resource to migrate to the inflammatory site, to generate reactive oxygen species using NADPH as a cofactor and to engulf bacteria or damaged tissue. The first responder cells of the innate immune response, neutrophils, are largely d...
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ژورنال
عنوان ژورنال: Cell Death & Differentiation
سال: 2004
ISSN: 1350-9047,1476-5403
DOI: 10.1038/sj.cdd.4401458